Written in English
|Statement||by Donald A. Kane.|
|The Physical Object|
|Pagination|| 110 leaves, bound :|
|Number of Pages||110|
The research project studying hydrazine in rats has revealed the following: 1) The uptake of hydrazine into the liver may be a saturable process; 2) After a hepatotoxic dose of hydrazine the Author: John Timbrell. chemicals. One of the primary ways hydrazine and 1,1-dimethylhydrazine enter the environment is from their use as rocket fuels. Accidental spills and leaks from storage and waste sites may add to environmental levels of hydrazines. Because 1,2-dimethylhydrazine is not used commercially and is produced only in small amounts, large releases to the. Biotransformation of Hydrazine Dervatives in the Mechanism of Toxicity Birandra K Sinha * and Ronald P Mason Laboratory of Pharmacology and Toxicology, National Institutes of Environmental Health. Methylhydrazine is used as a high-energy fuel in military applications. Acute (short-term) inhalation exposure to high levels of methylhydrazine may cause lacrimation, eye redness, nasal and respiratory irritation, headache, malaise, vomiting, diarrhea, ataxia, anoxia, cyanosis, tremors, and convulsions in .
Since hydrazine is a strong reductant and was observed as an intermediate in the Anammox process, we investigated whether the Anammox culture is able to use hydrazine as a substrate for growth. In order to gain more knowledge about the physiology of the hydrazine metabolism in Anammox, the research was focussed on three by: Under the authority of the Federal Advisory Committee Act (FACA) P.L. of , the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances (NAC/AEGL Committee) has been established to identify, review and interpret relevant toxicologic and other scientific data and develop AEGLs for high priority, acutely toxic chemicals. However, hydrazine at mu..g/g caused a significant reduction of soil bacterial populations, although fungal populations in soil were enhanced by the presence of hydrazine. Despite its toxicity to soil bacteria, hydrazine in small quantities was cometabolically degraded to nitrogen gas by Nitrosomonas. 1,2-dimethylhydrazine is a member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Hydrazine toxicity in brain RESULTS The compounds used in these studies were hydrazine, 1-methylhydrazine (MMH), U-dimethylhydrazine (UDMH), and 1,2-dimethylhydrazine (SDMH). The first three are toxic with the LD5o expressed as moles per kilogram body weight (2 x , 7 x , and 2 x lO"3 respectively).1 SDMH does not appear to be toxic Cited by: 4. Hydrazine has been used as a principal component of missile and rocket fuels and as a component of fuel cells used primarily for military applications. Hydrazine is a component of tobacco smoke. The quantity of hydrazine in mainstream cigarette smoke ranges from 24 to 43 nanograms (ng) per cigarette and averages 32 ng per cigarette (Liu et al. did predict additivity for depression of the central nervous system from exposure to jet fuels and tri chloroethylene and a greater-than-additive effect of strontium on arsenic toxicity due to inhibition by strontium of arsenic metabolism. Although the BINWOEs were indeterminate for all of the remaining pairs due to insufficient data, the. Abstract. Hydrazine (HzN) is an aircraft fuel and propellant used by the U.S. Air Force. The current study was undertaken to evaluate the acute toxicity of HzN in primary rat hepatocytes in vitro with reference to oxidative stress. The effects of short-term exposure (4 h) of hepatocytes to HzN were investigated with reference to viability, mitochondrial function, and biomarkers of oxidative Cited by: